| # | Bâtiment | Images | Hauteur | Nombre d'étages | Type de bâtiment | Année | État |
|---|---|---|---|---|---|---|---|
| 1 | Two Mercantile Center | 733 ft | 53 | gratte-ciel | 1976 | ||
| 2 | Gateway Arch | 30 | 630 ft | - | monument | 1965 | |
| 3 | One Metropolitan Square | 16 | 593 ft | 42 | gratte-ciel | 1989 | |
| 4 | One AT&T Center | 22 | 588 ft | 44 | gratte-ciel | 1986 | |
| 5 | Thomas F. Eagleton Courthouse | 15 | 557 ft | 28 | gratte-ciel | 2000 | |
| 6 | Central Tower | 486 ft | 40 | gratte-ciel | 1931 | ||
| 7 | US Bank Plaza | 7 | 484 ft | 35 | gratte-ciel | 1976 | |
| 8 | Laclede Gas Building | 11 | 401 ft | 31 | gratte-ciel | 1969 | |
| 9 | Southwestern Bell Building | 14 | 399 ft | 26 | gratte-ciel | 1926 | |
| 10 | Civil Courts Building | 11 | 386 ft | 13 | gratte-ciel | 1929 | |
| 11 | Bank of America Plaza | 11 | 384 ft | 31 | gratte-ciel | 1981 | |
| 12 | 600 Washington | 7 | 375 ft | 25 | gratte-ciel | 1985 | |
| 13 | Drury Tower | 350 ft | 30 | gratte-ciel | - | ||
| 14 | One Cardinal Way | 320 ft | 29 | immeuble | 2019 | ||
| 15 | The Tower at OPOP | 12 | 312 ft | 25 | immeuble | 2010 | |
| 16 | 1010 Market Street | 6 | 296 ft | 20 | immeuble | 1982 | |
| 17 | Millennium Hotel St. Louis Tower I | 10 | 289 ft | 28 | immeuble | 1968 | |
| 18 | Four Seasons Hotel St. Louis | 21 | 289 ft | 19 | immeuble | 2007 | |
| 19 | The Gentry's Landing | 2 | 287 ft | 28 | immeuble | 1965 | |
| 20 | Mansion House Apartments | 3 | 287 ft | 28 | immeuble | 1965 |